Chromium is a biological trace mineral that appears to support carbohydrate metabolism and healthy serotonin levels as well as support serum cortisol levels, which may support energy production and appetite regulation.

Moreover, vanadium has similar effects in the human body, acting to support healthy blood sugar and blood lipid levels . It is suggested that vanadyl sulfate modifies proteins in skeletal muscle that are involved in insulin signaling, which in turn supports healthy blood sugar balance.